张勃
张勃

特聘研究员

研究领域

神经生物学

个人邮箱

zbo@szbl.ac.cn

教育与工作经历

2020.05-至今     深圳湾实验室                    特聘研究员,课题组长

2019.01-至今     北京大学深圳研究生院            特聘研究员,博士生导师

2017.09-2018.12   斯坦福大学                      基础研究科学家

2011.09-2017.08   斯坦福大学/霍华德休斯研究所     博士后

2005.09-2011.07   北京大学                        博士

2001.09-2005.07   中央民族大学                    学士

研究方向

神经突触的形成和维持功能的分子基础,以及神经突触结构/功能障碍在神经和精神疾病中作用机理。

代表论文

Lloyd, B.A., Han, Y., Roth, R., Zhang, B., Aoto, J*. (2023). Neurexin-3 subsynaptic densities are spatially distinct from Neurexin-1 and essential for excitatory synapse nanoscale organization in the hippocampus. Nature Communications. 14, 4706. 10.1038/s41467-023-40419-2.


Zhu, F. #, Liu, L. #, Li, J. #, Liu, B., Wang, Q., Jiao R., Xu, Y., Wang, L., Sun, S., Sun, X., Younus, M., Wang, C., Hokfel, T., Zhang, B.*, Gu, H. *, Xu, Z. *, Zhou, Z. *. (2022). Cocaine increases quantal norepinephrine secretion through NET-dependent PKC activation in locus coeruleus neurons. Cell Reports. 40(7), 16 August 2022, 111199.


 https://doi.org/10.1016/j.celrep.2022.111199.


Han, Y#, Cao, R#, Qin, L., Chen, L., Tang, A., *, Südhof, TC*, Zhang, B*. (2022) Neuroligin-3 confines AMPA-receptors into nanoclusters, thereby controlling synaptic strength at the calyx of Held synapses. Science Advances. 8(24):eabo4173


Qin, L., Guo, S., Han, Y., Wang, X., Zhang, B*. (2020) Functional mosaic organization of neuroligins in neuronal circuits. Cellular and Molecular Life Sciences. 77, 3117-3127


Zhang, B.*,Gokce, O., Hale, D., Brose, N., Südhof, TC. (2018) Autism-associated Neuroligin-4 mutation selectively impairs glycinergic synaptic transmission in mouse brainstem synapses. Journal of Experimental Medicine. 215 (6): 1543-1553


Zhang, B.*,Seigneur, E., Wei, P., Gokce, O., Morgan, J., Südhof, TC. (2017) Developmental plasticity shapes synaptic phenotypes of autism-associated neuroligin-3 mutations in the calyx of Held. Molecular Psychiatry. 22, 1483–1491. [F1000 recommended]


Chen, L. #, Jiang, M. #, Zhang, B.,Gokce, O., Südhof, TC*, (2017). Conditional Deletion of All Neurexins Defines Diversity of Essential Synaptic Organizer Functions for Neurexins. Neuron, 94(3), 611-625.


Jiang, M. #, Polepalli, J. #, Chen, L., Zhang, B.,Südhof, TC*, Malenka, R*. (2017) Conditional ablation of neuroligin-1 in CA1 pyramidal neurons blocks LTP by a cell-autonomous NMDA receptor-independent mechanism.  Molecular Psychiatry. 22(3):375-383.


Zhang, B.*, Südhof, TC. (2016). Neuroligins are selectively essential for NMDA-receptor signaling in cerebellar stellate interneurons. J. Neurosci. 36(35):9070-9083. [F1000 recommended].


Zhang, B.#, Chen, L. #, Maxeiner, S., Lee, S., Gokce, O., Südhof, TC*. (2015) Neuroligins Sculpt Cerebellar Purkinje-Cell Circuits by Differential Control of Distinct Classes of Synapses. Neuron. 87(4):781-96. [Cover Story]