特聘研究员
细胞生物学
yincq@szbl.ac.cn
2020至今 深圳湾实验室 特聘研究员
2020 哈佛医学院/麻省总医院 博士后
2016-2020 波士顿大学 博士后
2016 德雷塞尔大学 博士
2010 中国科学技术大学 本科
课题组主要研究方向为代谢重编程和蛋白翻译后修饰在恶性肿瘤发生发展中的调控机制，综合运用蛋白质多组学、代谢组学、肿瘤生物学、基因编辑工程和高通量筛选等技术手段，结合临床样本以及肿瘤类器官和动物模型，揭示癌症发生发展的关键代谢和信号通路，以挖掘癌症治疗新靶点和开发治疗新策略。
Liu, D.#, Liang, C.#, Huang, B.#, Zhuang, X., Cui, W., Yang, L., Yang, Y., Zhang, Y., Fu, X., Zhang, X., Du, L., Gu, W., Wang, X., Yin, C.*, Chai, R.*, Chu, B.* Tryptophan metabolism acts as a new anti-ferroptotic pathway to mediate tumor growth. Advanced Science, 2023, 10(6), 2204006.
Liu, L. #, Zhou, Y. #, Luo, D. #, Sun, X., Li, H., Lu, Y., Wang, J., Zhang, M., Lin, N., Yin, C.*, Li, X.* Aberrant promoter methylation of Wnt inhibitory factor-1 gene is a potential target for treating psoriasis. Clinical Immunology, 2023, 252023, 0, 109294.
Sun, Y.#, Li, X.#, Yin, C.#, Zhang, J., Liang, E., Wu, X., Ni, Y., Arbesman, J., Goding, C. R., Chen, S. AMPK phosphorylates ZDHHC13 to increase MC1R activity and suppress melanomagenesis. Cancer Research, 2023, 83 (7): 1062–1073.
Yin, C.#, Zhu, B.#, Zhang, T.#, Liu, T.#, Chen, S., Liu, Y., Li, X., Miao, X., Li, S., Mi, X., Zhang, J., Li, L., Wei, G., Xu, Z., Gao, X., Huang, C., Wei, Z., Goding, C. R., Wang, P.*, Deng, X.*, Cui, R.* Pharmacological targeting of STK19 inhibits oncogenic NRAS-driven melanomagenesis. Cell, 2019, 176(5), 1113-1127.
Zhu, B.#, Chen, S.#, Wang, H.#, Yin, C.#, Han, C.#, Peng, C., Liu, Z., Wan, L., Zhang, X., Zhang, J., Lian, C. G., Ma, P., Xu, Z., Prince, S., Wang, T., Gao, X., Shi, Y., Liu, D., Liu, M., … Chen, X.*, Zhou., J.*, Cui, R.* The protective role of DOT1L in UV-induced melanomagenesis. Nature Communications, 2018, 9(1), 1-13.
Zhu, B.#, Tang, L.#, Chen, S.#, Yin, C.#, Peng, S.#, Li, X., Liu, T., Liu, W., Han, C., Stawski, L., Xu, Z., Zhou, G., Chen, X., Gao, X., Goding, C. R.*, Xu, N.*, Cui, R.*, Cao, P.* Targeting the upstream transcriptional activator of PD-L1 as an alternative strategy in melanoma therapy. Oncogene, 2018, 37(36), 4941-4954.
Chen, S.#, Zhu, B.#, Yin, C.#, Liu, W., Han, C., Chen, B., Liu, T., Li, X., Chen, X., Li, C., Hu, L., Zhou, J., Xu, Z., Gao, X., Wu, X., Goding, C. R., Cui, R. Palmitoylation-dependent activation of MC1R prevents melanomagenesis. Nature, 2017, 549(7672), 399-403.
