课题组主要针对“阿尔茨海默病(Alzheimer’s disease, AD)的临床演化规律及早期诊疗”相关的科学问题，基于AD队列的多模态神经影像和生物标记物数据，系统探究AD发生发展中Aβ、tau、神经免疫、神经突触、脑结构萎缩和糖代谢缺失等病理的临床演化规律及发病机制，旨在构建基于PET分子影像的AD影像病理精准分级和早期诊断方法，阐明了AD发生发展中体液生物标记物的演化规律,进而建立基于外周血中Aβ病理、tau病理以及神经变性等血浆生物标记物的AD早期筛查方案。此外，课题组还借助于AD类器官或者动物模型进一步揭示AD的病理特征及发病机制，开发AD早期非药物干预新技术。

近期代表性论:

Guoyu Lan, Xuhui Chen, Jie Yang, Pan Sun, Yue Cai, Anqi Li, Yalin Zhu, Zhen Liu, Shaohua Ma, Tengfei Guo*. “Microglial reactivity correlates to presynaptic loss independent of β-amyloid and tau”. Annals of Neurology, 2024, DOI: 10.1002/ana.26885 (独立通讯作者).

Yue Cai, Dai Shi, Guoyu Lan, Linting Chen, Yanni Jiang, Liemin Zhou, Tengfei Guo*. “Association of β-amyloid, microglial activation, cortical thickness, and metabolism in older adults without dementia”, Neurology, 2024, DOI: 10.1212/WNL.0000000000209205 (独立通讯作者).

Jing Du, Anqi Li, Dai Shi, Xuhui Chen, Qingyong Wang, Zhen Liu, Kun Sun, Tengfei Guo*. “Association of APOE4, osteoarthritis, β-amyloid, and tau accumulation in primary motor and somatosensory regions in Alzheimer’s Disease”, Neurology, 2023, 101(1): e40-e49 (独立通讯作者).

Guoyu Lan, Anqi Li, Zhen Liu, Shaohua Ma, Tengfei Guo*. “Presynaptic membrane protein dysfunction occurs prior to neurodegeneration and predicts faster cognitive decline”, Alzheimer’s & Dementia, 2023, 19 (6): 2408-2419 (独立通讯作者).